Antimicrobial Peptides: Role in Human Health and Disease by Jürgen Harder, Jens-M. Schröder PDF

By Jürgen Harder, Jens-M. Schröder

ISBN-10: 3319241974

ISBN-13: 9783319241975

ISBN-10: 3319241990

ISBN-13: 9783319241999

This booklet makes a speciality of the significance of human antimicrobial peptides (AMP) in holding the host fit and fighting infectious illnesses. the 1st chapters care for a number of examples of the position of AMP in several epithelial organs (skin and wound therapeutic, eye, lung, genito-urinary tract, gut), that are uncovered to other kinds of infectious microorganisms and for that reason produce varied styles of AMP. Examples of the dysregulation of AMP expression and serve as selling infections are mentioned. The ability of AMP to limit the supply of crucial metals to micro organism as an effective antibacterial process in dietary immunity is mentioned within the subsequent bankruptcy. Our present knowing of ways nutrition D, the light diet, impacts AMP-expression and the way this may impact our wellbeing and fitness is usually addressed. final yet now not least, the position of AMP in HIV an infection and the immunomodulatory houses of AMP spotlight the varied features of AMP in host immunity. AMP’s particular features, together with in struggling with multi-resistant micro organism, recommend that they might provide healing advantages – a question that's mentioned within the ultimate chapter.

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2004; Soong et al. 1997). Moreover, enhanced levels of cathelicidin correlate with severity of CF lung disease (Chen et al. 2004). β-Defensin levels do not seem to correlate with the severity of inflammation, but decreased levels of hBD-2 are associated with severity of CF (Chen et al. 2004; Dauletbaev et al. 2002; Bals et al. 2001). In vitro, the bactericidal activity of cationic AMPs is salt sensitive. Thus, it is suggested that increased salt concentrations in airway fluids of CF patients contribute to chronic lung infection by inhibiting bactericidal functions of AMPs (Bals et al.

2 Chronic Lung Diseases Cigarette smoke is the major risk factor for the development of the chronic obstructive pulmonary disease (COPD). COPD is characterized by chronic inflammation of the lung leading to tissue destruction, emphysema, and loss of pulmonary function (Sethi and Murphy 2008; Sethi 2010). , H. influenzae); recurrent infections of the 3 Function of Antimicrobial Peptides in Lung Innate Immunity 43 respiratory tract and chronic bronchitis are common in COPD (Sethi and Murphy 2008; Sethi 2010; Moghaddam et al.

Am J Respir Cell Mol Biol 30: 193–201 Aerts AM, François IEJA, Cammue BPA, Thevissen K (2008) The mode of antifungal action of plant, insect and human defensins. Cell Mol Life Sci 65:2069–2079 Agerberth B, Grunewald J, Castaños-Velez E et al (1999) Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. Am J Respir Crit Care Med 160:283–290 Akira S (2009) Pathogen recognition by innate immunity and its signaling. Proc Jpn Acad Ser B Phys Biol Sci 85:143–156 Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity.

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Antimicrobial Peptides: Role in Human Health and Disease by Jürgen Harder, Jens-M. Schröder


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