Annual Reviews's Annual Review of Immunology Volume 27 2009 PDF

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Org by University of Bergen UNIVERSITETSBIBLIOTEKET on 01/13/09. For personal use only. 6 Wang et al. nal orientation (Figure 3b) (14). Binding measurements have also confirmed that LIFR and CNTF alone interact via a high-affinity site III that is presumably analogous to that of the LIF/LIFR interaction. A recent single-particle EM analysis of full-length gp130 and LIFR in complex with CNTFRα and CNTF (76) has confirmed the architecture of the quaternary gp130/LIFR/CNTFRα/CNTF complex proposed in Boulanger et al.

In neurobiology, the p75 neurotrophin receptor can recognize a family of neurotrophic factors, including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 (2). The glial cell line–derived neurotrophic factor family ligands, which include glial cell line–derived neurotrophic factor, neurturin, artemin, and persephin, share the RET receptor as the signaling subunit in their receptor complexes (3). In the immune system, shared receptors exist in both adaptive (T cell receptors, costimulatory molecules B7/CD28) (4) and innate immunity (NKG2D natural killer receptor, scavenger, and pattern-recognition receptors such as RAGE and Toll) (5).

Org by University of Bergen UNIVERSITETSBIBLIOTEKET on 01/13/09. For personal use only. 116. Nishimoto N, Kishimoto T. 2006. Interleukin 6: from bench to bedside. Nat. Clin. Pract. Rheumatol. 2:619–26 117. Maini RN, Taylor PC, Szechinski J, Pavelka K, Broll J, et al. 2006. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 54:2817–29 118.

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