Annual Review of Immunology Volume 25 2007 by Annual Reviews PDF

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1995. The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol. Rev. 75:591–609 43. Johansen FE, Braathen R, Brandtzaeg P. 2001. The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgA. J. Immunol. 167:5185–92 44. Royle L, Roos A, Harvey DJ, Wormald MR, van Gijlswijk-Janssen D, et al. 2003. Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J. Biol. Chem. 278:20140–53 45. Wiersma EJ, Collins C, Fazel S, Shulman MJ.

Vaccine design: Structural analysis of the binding sites of high-affinity anticarbohydrate antibodies complexed with their ligands would facilitate rational design of vaccines that will raise antibodies targeted to glycan epitopes in microorganisms and in cancer. 3. Therapeutic antibodies: Continued development of antibodies with fully “humanized” glycosylation in plants and yeast systems could further the production of cheap, nonimmunogenic therapeutic antibodies. 4. , in serum) that bind to aberrant glycans in diseases such as cancer.

286:1421–47 77. Zhu D, McCarthy H, Ottensmeier CH, Johnson P, Hamblin TJ, Stevenson FK. 2002.

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Annual Review of Immunology Volume 25 2007 by Annual Reviews

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