Read e-book online AIDS-Associated Viral Oncogenesis (Cancer Treatment and PDF

By Craig Meyers

ISBN-10: 0387468048

ISBN-13: 9780387468044

ISBN-10: 0387468161

ISBN-13: 9780387468167

One of crucial elements of AIDS is the lack of protecting immune functionality within the contaminated host which ends up in elevated occurrence of opportunistic infections and cancers. This e-book particularly addresses viral-induced human cancers linked to AIDS and saw within the AIDS inhabitants. It addresses the explicit therapy required during this precise inhabitants and the molecular biology of the causative viral agents.

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Additional resources for AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research)

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5 cases/1,000 p-y post-HAART (p-value not significant). 86,87 The IPI includes clinical features that reflect the growth and invasive potential of the tumor (tumor stage, serum LDH level, and number of extranodal disease sites), the patient’s response to the tumor (performance status), and the patient’s ability to tolerate Table 3. 5-Year relapse-free and overall survival rates according to the International Prognostic Index (IPI) and age-adjusted IPI (adapted from references86)87 Risk group Number of adverse factors* Low Low-intermediate High-intermediate High 0 or 1 2 3 4 or 5 Low Low-intermediate High-intermediate High 0 1 2 3 5-Year relapse survival (%) 5-Year overall survival (%) International prognostic index 70 50 49 40 73 51 43 26 Age-adjusted international prognostic index * 86 66 53 58 83 69 46 32 Adverse risk factors for IPL are: stage III or IV disease, age > 60 years, elevated lactate dehydrogenase (LDH), and performance status ≥ 2, ≥2 extranodal sites.

2 months in DLBCL). 65 Cortes and colleagues used HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high-dose methotrexate and cytarabine) regimen in 13 patients with HIV-related BL, nine of whom also received HAART. 66 While Wang and colleagues, in a retrospective study, compared 14 HIV-infected individuals with BL with 24 non-HIV-infected individuals with BL who received CODOX-M/IVAC (cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine) or less intensive regimens.

AIDS-related lymphomas (WHO classification)54 Lymphomas also occurring in immunocompetent patients Burkitt’s lymphoma DLBCL: centroblastic, immunoblastic, and anaplastic variants Lymphomas occurring more specifically in HIV-infected patients Primary effusion lymphoma Plasmablastic lymphoma Lymphomas also occurring in other immunodeficiency states Polymorphic or post-transplant lymphoproliferative disorder-like B-cell lymphoma 2. 56 TREATMENT OF AIDS-RELATED BL In regards to treatment, current studies have uniformly targeted intermediategrade DLBCL and high-grade BL in HIV-infected individuals.

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AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research) by Craig Meyers


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