By Frederick W. Alt
Advances in Immunology, a customary and hugely revered book, provides present advancements in addition to complete studies in immunology. Articles handle the big variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored through the major scientists within the box, each one quantity offers up to date info and instructions for destiny * Contributions from best professionals and specialists * Informs and updates on all of the most modern advancements within the box
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Advances in Immunology, a usual and hugely revered booklet, provides present advancements in addition to complete studies in immunology. Articles tackle the wide variety of themes that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities.
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Extra resources for Advances in Immunology, Vol. 102
Endogenous ceramides have also been proposed as iNKT cell antigens. , 2004b). This hypothesis was based on the observation that mice deficient in b-hexosaminidase (HexB), an enzyme catalyzing the degradation of iGb4 into iGb3, had severely decreased numbers of iNKT cells, and that iNKT cells lacked autoreactivity to HexBÀ/À APCs. However, the major pathway for biosynthesis of the entire isoglobo series of glycosphingolipids (GSLs) from lactosylceramide is mediated by the enzyme iGb3 synthase. , 2007) makes it unlikely that iGb3 is the main selecting self-lipid in murine iNKT cell development.
2003). , 2008). , 2001a, 2003). , 2001). , 2007). 42 Nadia R. Cohen et al. 2. 1) reflects the remarkable versatility of these cells. Through rapid production of an array of cytokines as well as cell-to-cell interactions, iNKT cells can play an important role in selective recruitment, activation and polarization of both the innate (Fig. 7) and adaptive (Fig. 8) immune system. In addition, many iNKT cells are thought to possess cytotoxic potential, suggesting they may contribute directly to the destruction of intracellular pathogens.
Although human blood monocytes lack expression of CD1a, b, and c, all three of the Group I CD1 isoforms are upregulated during the process of myeloid DC differentiation. CD1a, b, and c expression on myeloid DC often serve as DC markers (Brigl and Brenner, 2004) but the pattern of expression may vary among DC subsets. Studies on human DC employ in vitro differentiation systems to complement analysis in vivo. Depending on the culture conditions, blood monocyte-derived DC can express CD1a, b, and c or alternatively, lack expression of CD1a but still Antigen Presentation by CD1: Lipids, T Cells, and NKT Cells 29 express CD1b and c.
Advances in Immunology, Vol. 102 by Frederick W. Alt