By Zoltan A. Nagy
A historical past of recent Immunology: A direction towards Understanding describes, analyzes, and conceptualizes a number of seminal occasions and discoveries in immunology within the final 3rd of the twentieth century, the period while so much questions on the biology of the immune method have been raised and in addition came upon their solutions. Written through an eyewitness to this heritage, the booklet provides perception into own elements of the real figures within the self-discipline, and its facts pushed emphasis on realizing will profit either younger and skilled scientists.
This ebook offers a concise creation to subject matters together with immunological specificity, antibody range, monoclonal antibodies, significant histocompatibility advanced, antigen presentation, T cellphone biology, immunological tolerance, and autoimmune illness. This huge heritage of the self-discipline of immunology is a necessary better half for college students of immunology, examine and medical immunologists, and examine managers within the pharmaceutical and biotechnology industries.
- Contains the historical past of significant breakthroughs in immunology featured with authenticity and insider details
- Gives an perception into own points of the avid gamers within the historical past of immunology
- Enables the reader to acknowledge and choose facts of heuristic worth which elucidate very important aspects of the immune system
- Provides sturdy examples and guidance for the popularity and choice of what's vital for the exploration of the immune system
- Gives transparent separation of descriptive and interpretive elements, permitting the reader to tell apart among proof and research supplied by way of the author
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Extra resources for A History of Modern Immunology. The Path Toward Understanding
The biological approach to estimating the size of repertoire was based on functional and evolutionary considerations. The starting point was a very simple thesis, which was so self-evident that most immunologists were embarrassed for not coming to it before. This was the following: ‘antibodies function 28 PART | II The History concentration dependent’. 10 Because the immune system is selected through the efficiency of its effector function (capability to eliminate pathogens), antibodies below the effective concentration would be unselectable.
2001;13:1361. 1 DISCOVERY The clonal selection theory has predicted that a single B cell and its descendants would produce one single antibody both as a cell surface receptor and in secreted form. 1). However, a direct proof entailing the isolation and expansion of single B cells and investigation of the antibody they secrete was difficult to obtain. The major obstacle to this was the technical unfeasibility to grow B cells long term, in vitro. The idea of how to get around this problem came from César Milstein, an experienced molecular biologist and immunologist at the MRC Laboratory of Molecular Biology in Cambridge, UK, and a young German immunologist, Georges Köhler, who spent his postdoctoral fellowship in Milstein’s laboratory.
Immunitätsforsch. 1917;26:293. Talmage DW. Science 1959;129:1643. Lederberg J. Science 1959;129:1649. Tonegawa S. Nature 1983;302:575. Griffiths GM, Berek C, Kaartinen M, Milstein C. Nature 1984;312:271. Langman RE, Cohn M. Mol. Immunol. 1987;24:675. Cohn M, Langman RE. Immunol. Rev. 1990;115:7. Cohn M. Cell. Immunol. 1997;181:103. Langman RE. Mol. Immunol. 2000;37:555. Percus JK, Percus OE, Perelson AS. Proc. Natl. Acad. Sci. USA 1993;90:1691. Parnes O. Mol. Immunol. 2004;40:985.
A History of Modern Immunology. The Path Toward Understanding by Zoltan A. Nagy