New PDF release: 200 years of least squares method

By Abdulle A., Wanner G.

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Chesler, D. , Goldberg, I. , Weisskoff, R. , Poncelet, B. , et al. (1992). Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proceedings of the National Academy of Sciences USA 89, 5675–5679. Lee, A. , Glover, G. , & Meyer, C. H. (1995). Discrimination of large venous vessels in time-course spiral blood-oxygen-level-dependent magnetic-resonance functional neuroimaging. Magnetic Resonance in Medicine 33, 745–754. , & Grinvald, A. (1996). Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: Implications for functional brain mapping.

1999). , EEG, MEG). These techniques are capable of meaningful, rapid measurements of brain activity but, today, provide relatively coarse spatial resolution. , 1995). Using such methods, it may become possible to study the precise spatiotemporal orchestration of neuronal activity associated with cognitive processes. Event-related fMRI allows a refinement of such integration by affording the ability to study the same paradigms in both fMRI settings and during EEG and MEG sessions. Several investigators have suggested that EEG could be conducted simultaneously with fMRI or PET measurements.

In addition, compared to PET, fMRI is relatively inexpensive and can be performed on scanners already available within most major hospitals, positioning it as a method available for widespread clinical use. However, fMRI does have disadvantages in regard to PET in that it is is extremely sensitive to a number of artifacts that can impede examination of brain function, especially brain motion, which poses one of the most severe challenges to fMRI data collection. Brain motion arising from many sources, such as subject movement or even motion on the order of millimeters associated with the respiratory and cardiac cycles, can disrupt the ability to acquire PET and fMRI Methods 31 fMRI data.

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200 years of least squares method by Abdulle A., Wanner G.


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